Centerville is a census-designated place in Anderson County, South Carolina. The population was 7,185 at the 2020 census. Centerville is a suburban area in central Anderson County located at 34°31′21″N 82°42′53″W / 34.52250°N 82.71472°W, west of Anderson, the county seat. Interstate 85, the primary highway through Upstate South Carolina, i…Centerville is a census-designated place in Anderson County, South Carolina. The population was 7,185 at the 2020 census. Centerville is a suburban area in central Anderson County located at 34°31′21″N 82°42′53″W / 34.52250°N 82.71472°W, west of Anderson, the county seat. Interstate 85, the primary highway through Upstate South Carolina, is 4 miles to the north at Exit 19. Lake Hartwell is 2 miles to the west.
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