The activation of the adenosine A2A receptor, which is mediated by the inhibition of adenosine A1 receptor, has been associated with depression-like behavior and anhedonia. High levels of cortisol, ...

Here’s why. You may feel sleepy after drinking coffee because caffeine blocks adenosine receptors in the brain. Adenosine is an important brain chemical that impacts our sleep-wake cycles.

Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...