Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene ... the p53 deletions frequently encompass many other genes. Using chromosome ...

d, Biallelic silencing of both gene copies without LOH or gene mutation. e,f, Haploinsufficient tumor-suppressor genes do not need to lose both functional copies to confer increased risk.

The Dere Lab is actively working on understanding and evaluating the crosstalk between tumor suppressors lost as part of chromosome 3p deletion associated with ... loss of the von Hippel Lindau (VHL) ...

Tumor suppressor p53 limits the ... Thompson and Compton engineered a human cell line to carry a unique fluorescent mark on one of its chromosomes. This allowed them to identify and follow by ...