In view of this complexity, how can we identify the specific oncogene or oncogenes that have a critical role in maintaining the malignant phenotype in these different cancer types, or within ...

serving as a foundation for the now widely accepted phenomenon called oncogene addiction 11. But the euphoria of blast-crisis remissions was short lived. Despite continued imatinib treatment ...

We previously introduced the concept of 'oncogene addiction' to explain how some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities are dependent on or 'addicted' to ...