An investigation of the structural assembly between receptors involved in dimerization showed that there are several sites of interaction including hydrophobic transmembrane domain interactions ...

because they do not cause behavioral signs associated with activation of either normosensitive or supersensitive postsynaptic dopamine D 2 receptors (e.g., increased locomotion in reserpinized ...

Eating certain foods, like those high in protein, and healthy practices like exercising and sleeping the recommended amount can help increase your body’s dopamine levels without medication.

In the nucleus accumbens, new subsets of dopamine receptors flourish at synapses to deliver the capacity to get excited by other goals and especially by connection to others. People regain the ...

Despite being a first-line treatment for adolescent depression and anxiety, antidepressant drugs appear to have questionable efficacy and carry an increased risk of adverse effects in this ...

The common aphorism 'start low and go slow' seems to dictate a widely accepted guiding principle for drug prescription in older adults. For those with late-life psychiatric conditions, attaining ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The mechanisms underlying the onset and progression of chronic pain in COVID-19 ...

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the ...

This study uses state-of-the-art methods to label endogenous dopamine receptors in a subset of Drosophila mushroom body neuronal types. The authors report that Dop1R1 and Dop2R receptors, which have ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...

This cytoplasmic tail also contains the palmitoylation sites of S protein. Protein palmitoylation modification of S protein could be catalyzed by a family of zinc finger DHHC domain-containing ...