An investigation of the structural assembly between receptors involved in dimerization showed that there are several sites of interaction including hydrophobic transmembrane domain interactions ...

The ligand binds to a site in the extracellular domain of the receptor (not shown) and induces a conformational change that activates the cytoplasmic domains, enabling interaction and assembly of ...

Recently, timed-release bromocriptine (Cycloset), a sympatholytic dopamine D 2 receptor agonist, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes.