Cancer cells have special adaptation mechanisms that allow them to proliferate despite changes in their genetic makeup.

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body’s immune response ...

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

Cancer cells have special adaptation mechanisms that allow them to proliferate despite changes in their genetic makeup.

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene ... the p53 deletions frequently encompass many other genes. Using chromosome ...

d, Biallelic silencing of both gene copies without LOH or gene mutation. e,f, Haploinsufficient tumor-suppressor genes do not need to lose both functional copies to confer increased risk.

These findings provide evidence that promoter methylation of Dkk-3 is a common event in gastric cancer and that Dkk-3 is a tumor suppressor gene through the inhibition of Wnt signaling.

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response ...

The Dere Lab is actively working on understanding and evaluating the crosstalk between tumor suppressors lost as part of chromosome 3p deletion associated with ... loss of the von Hippel Lindau (VHL) ...