e,f, Haploinsufficient tumor-suppressor genes do not need to ... Some 'low-penetrance' tumor susceptibility genes may be in this category.

There are two types of genes that are important in the development and growth of cancers: oncogenes and tumor-suppressor genes. Most often, an accumulation of mutations in both oncogenes and tumor ...

Can tumor suppressor genes and proto-oncogenes provide clues ... A recent high-throughput study shows that some types of cancer are associated with mutations in a specific proto-oncogene or ...

These findings provide evidence that promoter methylation of Dkk-3 is a common event in gastric cancer and that Dkk-3 is a tumor suppressor gene through the inhibition of Wnt signaling.

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body’s immune response ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...