In the latest 2025 NFL mock draft for ESPN, the San Francisco 49ers have a clear direction in which they want to head. ESPN’s Matt Miller shared his latest two-round mock draft following the Senior Bowl and Shrine Bowl all-star events. It has the 49ers looking to the trenches for help.

Following a disappointing 6-11 season, the 49ers are uniquely positioned for a quick bounce-back, especially if they can get a second-straight quality draft class. After years of

San Francisco is projected to land four comp picks, and their seventh-round choice via the Panthers came in a trade last year that landed kicker Zane Gonzalez with the 49ers. It’s unclear what the conditions of the pick swap were, so there’s a chance San Francisco actually holds onto its own pick, which is slated for No. 229.

NFL.com's Eric Edholm released his first mock draft of the year, projecting which first-year players each team will select in April. The San Francisco 49ers hold the No.