An investigation of the structural assembly between receptors involved in dimerization showed that there are several sites of interaction including hydrophobic transmembrane domain interactions ...

Striatal dopamine (DA) release regulates reward-related learning and behavioural activation and is believed to consist of a short-lived phasic and continuous tonic component. Here, we build a ...

Repeated drug use physically changes dopamine receptors, reducing sensitivity and leading to tolerance (needing more of the substance to achieve the same effect). Over time, natural rewards (like ...

In the nucleus accumbens, new subsets of dopamine receptors flourish at synapses to deliver the capacity to get excited by other goals and especially by connection to others. People regain the ...

Despite being a first-line treatment for adolescent depression and anxiety, antidepressant drugs appear to have questionable efficacy and carry an increased risk of adverse effects in this ...

The common aphorism 'start low and go slow' seems to dictate a widely accepted guiding principle for drug prescription in older adults. For those with late-life psychiatric conditions, attaining ...

💡 Tip: You don’t need an intense workout—just 30 minutes of brisk walking, dancing, or even yoga can provide a significant dopamine boost.

This study uses state-of-the-art methods to label endogenous dopamine receptors in a subset of Drosophila mushroom body neuronal types. The authors report that Dop1R1 and Dop2R receptors, which have ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...

Discoidin domain receptor 1 (DDR1) has been demonstrated to be able to promote tumor invasion and metastasis and being closely related to tumor immune infiltration. However, DDR1 has rarely been ...

Dopamine 2 receptor (D2R) is a host receptor positively associated with DENV infection. Metoclopramide (MCP), a D2R antagonist clinically used to control vomiting and nausea in patients with DENV ...