The Dere Lab is actively working on understanding and evaluating the crosstalk between tumor suppressors lost as part of chromosome 3p deletion associated with ... loss of the von Hippel Lindau (VHL) ...

Cancer cells have special adaptation mechanisms that allow them to proliferate despite changes in their genetic makeup.

Cancer cells have special adaptation mechanisms that allow them to proliferate despite changes in their genetic makeup.

WWP1 demonstrates a dual function, acting predominantly as an oncogene in tumors but occasionally as a tumor suppressor. This review summarizes ... and associated signaling pathways in human cancers ...

found a panel of 9 serum-derived extracellular vesicles-miRNAs (miRNA-200c-3p, miRNA ... 16–5p is located at chromosome 13q14 and it is downregulated in LNCaP cells. Wang et al. showed that this miRNA ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body’s immune response ...

These findings provide evidence that promoter methylation of Dkk-3 is a common event in gastric cancer and that Dkk-3 is a tumor suppressor gene through the inhibition of Wnt signaling.