May 21, 2024 · To understand neoantigens, we first need to define what an antigen is. Antigens are substances that induce the immune system to produce antibodies against that material (literally an antibody generator). 1 Antigens are commonly abbreviated as Ag. Examples of neoantigens include proteins or sugar molecules (polysaccharides) located on the outside of cells.

Sep 16, 2024 · What have HeLa cells been used for? HeLa cells have played a role in some of the major advances in fields such as cancer biology, infectious disease and fundamental microbiology.Some of the research involving HeLa cells also served as the underpinning of several Nobel Prize-winning discoveries such as the 2014 Nobel Prize in Chemistry for the development of a microscope technique that allows ...

Jan 24, 2024 · The competitive landscape throughout the drug development process requires research scientists to apply rigorous qualitative and quantitative analyses to bring lead drug candidates to market quickly. In this article, we will discuss what is meant by drug metabolism and pharmacokinetics (DMPK) and explore its role in various stages of pharmaceutical development.

Jul 7, 2023 · For many years, research has focused on regeneration of sensory hair cells. Although those efforts continue, it is equally important to better understand the mechanisms that govern repair and maintenance of the cells, said researcher Jung-Bum Shin, of UVA’s Department of Neuroscience.

Jan 4, 2024 · As mentioned, different types of genetic modification can be made, including: Gene knockout – the removal or inactivation of a target gene.; Deletion mutation – the removal of one or more nucleotides from a genetic sequence.; Insertion mutation – the addition of one or more nucleotides into a genetic sequence.; Substitution mutation – the switching out of one or more nucleotides in a ...

Oct 28, 2024 · With these immense technological advances, the human genome project was completed in 2003. 9 In 2005, the first commercially available NGS platform, or second generation (2G) as it has become, was introduced, able to amplify millions of copies of a particular DNA fragment in a massively paralleled way in contrast to Sanger sequencing. 10 …

Glen Research, part of Maravai LifeSciences, is a leading provider of reagents for DNA and RNA oligonucleotide synthesis, labeling and modification. Known for its proprietary Sterling^™ line of reagents marked with its Sterling seal of quality assurance, Glen Research analyzes and certifies these reagents for purity and performance, ensuring consistent, dependable and reliable ...

May 2, 2024 · Diagnostic testing is key in many areas including healthcare and preventative medicine, food safety and environmental monitoring. As such, analysts need appropriate and accurate assays suited to the sample type, analyte and testing environment that respect monetary, time and operator constraints.

Feb 8, 2023 · How does super-resolution microscopy work?. There are three main types of super-resolution microscopy, each one working via a different mechanism. These include stimulated emission depletion (STED) microscopy, structured illumination microscopy (SIM), and stochastic optical reconstruction microscopy (STORM)/photoactivation localization microscopy (PALM).

Jan 24, 2024 · Assays in drug discovery fall into two main categories: biochemical assays and cell-based assays. Biochemical assays are often the first type of assay used. Biochemical assays are valuable for evaluating and examining the target protein and identifying the compounds that possess the desired activity at the target.